2-Methoxymethyl-Salvinorin B - is a C(2) derivative of Salvinorin A. The added Methoxy and methyl groups not only make it 7-fold more potent than Salvinorin A, they also make it harder to breakdown and prolong duration. It has been shown to last 2-3 hours as compared to 10-20 minutes with Salvinorin A.

I can't decided whether this is mind blowingly awesome, or that they've created a monster. I mean, can you imagine being in Saliva space for 3 hours......? And I imagine the effects will be more intense as well, as is the case with methamphetamine compared to amphetamine.

Herkinorin - Another Salvinorin A analogue made from Salvinorin B, has been tweaked so that instead of binding to κ-opioid receptors it binds to μ-opioid receptors. It's said to be the the same strength as Fentanyl which is 81 times more potent than morphine. It's not orally effective like 2-Methoxymethyl-Salvinorin B and can either be taken sublingually, smoked, and maybe injected. Not too sure about that last one.

It causes similar effects to other strong opiates as well as respiratory depression which could be fatal. On the plus side, so far it has been demonstrated not to cause tolerance or dependence like other opiates do. So it could be a great alternative to treating chronic pain, etc.

There's also a C(4) derivative by the name of N-Methylamide-Salvinorin A that I'm trying to get info on. It may be even more potent than 2-Methoxymethyl-Salvinorin B.

What do you think about this? Is it madness, or do you think they may have potential, and could even be used as the psychedelics of the future???